Antibacterial property and clinical effect of gatifloxacin, a novel quinolone antibacterial agent.
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bacteriophage as a novel antibacterial agent in industry and medicine
bacteriophage is a kind of virus that infect bacteria, and is distinct from the animal and plant viruses that could have either lytic or lysogenic cycle. lytic phages known as candidates for phage therapy, since they rapidly replicate into their host and lyse them. theoretically, phages have more than a few benefits over routine antibiotics. they are extremely specific and for their targeted ho...
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486 Communications to the Editor well described by Pepe and Marini#{176}and is an important cause of hypotension in mechanically ventilated patients. The lungs are unable to exhale to FRC at the start of the next mechanically initiated inspiration because of airway obstruction. Positive end expiratorv intrathoracic pressure builds up, although this cannot be shown on the ventilator manometer. T...
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OBJECTIVE Quinolone moiety is an important class of nitrogen containing heterocycles widely used as key building blocks for medicinal agents. It exhibits a wide spectrum of pharmacophores and has bactericidal, antiviral, antimalarial, and anticancer activities. In view of the reported antimicrobial activity of various fluoroquinolones, the importance of the C-7 substituents is that they exhibit...
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The distribution of HSR-903, a new quinolone antibacterial agent, to the brain after i.v. administration to rats was low compared with that to other tissues. The blood-brain barrier permeability to HSR-903 determined by the brain perfusion method was low, and increased nonlinearly with increasing concentration of HSR-903 in the perfusate. When the brain-to-plasma concentration ratio (Kp, brain)...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2003
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.121.447